Interleukin 4 drives phytohemagglutinin-activated T cells through several cell cycles: no synergism between interleukin 2 and interleukin 4

  • Cell kinetic studies of T cells stimulated with the interleukin 2 (11-2), D-4, or both lymphokines were performed with conventional [3H] thymidine incorporation and with the bivariate BrdU/Hoechst technique. 11-2 and 11-4 are able to drive phytohemagglutininactivated T cells through more than one cell cycle. Neither synergistic nor inhibitory efl'ect on T -cell proliferationwas seen for the stimulation with both 11-2 and 11-4 as compared with the effect ofll-2 alone. The quantitative data ofthe cell cycle distribution ofphytohemagglutininactivaCell kinetic studies of T cells stimulated with the interleukin 2 (11-2), D-4, or both lymphokines were performed with conventional [3H] thymidine incorporation and with the bivariate BrdU/Hoechst technique. 11-2 and 11-4 are able to drive phytohemagglutininactivated T cells through more than one cell cycle. Neither synergistic nor inhibitory efl'ect on T -cell proliferationwas seen for the stimulation with both 11-2 and 11-4 as compared with the effect ofll-2 alone. The quantitative data ofthe cell cycle distribution ofphytohemagglutininactivated T cells suggestthat the population ofll-4-responsive cells is at least an overlapping population, if not a real subset of the ·population of the 11-2-responsive cells.show moreshow less

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Metadaten
Author: T. Lehrnbecher, H. Merz, Walter Sebald, M. Poot
URN:urn:nbn:de:bvb:20-opus-62491
Document Type:Journal article
Faculties:Theodor-Boveri-Institut für Biowissenschaften
Language:English
Year of Completion:1991
Source:In: Cytokine (1991 Nov) 6, 3, 593-597.
Dewey Decimal Classification:570 Biowissenschaften; Biologie
GND Keyword:Biochemie
Tag:BrdU-Hoechst; cell cycle; flow cytometry; interleukin 2; interleukin 4
Release Date:2012/03/20
Licence (German):License LogoDeutsches Urheberrecht