TY - JOUR A1 - Fraunholz, Martin A1 - Sinha, Bhanu T1 - Intracellular staphylococcus aureus: Live-in and let die T2 - Frontiers in Cellular and Infection Microbiology N2 - Staphylococcus aureus uses a plethora of virulence factors to accommodate a diversity of niches in its human host. Aside from the classical manifestations of S. aureus-induced diseases, the pathogen also invades and survives within mammalian host cells. The survival strategies of the pathogen are as diverse as strains or host cell types used. S. aureus is able to replicate in the phagosome or freely in the cytoplasm of its host cells. It escapes the phagosome of professional and non-professional phagocytes, subverts autophagy, induces cell death mechanisms such as apoptosis and pyronecrosis, and even can induce anti-apoptotic programs in phagocytes. The focus of this review is to present a guide to recent research outlining the variety of intracellular fates of S. aureus. KW - staphylococcus aureus KW - bacterial persistence KW - host cell death KW - autophagy KW - phagocytosis KW - phagosomalescape Y1 - 2012 UR - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/12337 UR - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-123374 VL - 2 IS - 43 ER -