TY  - JOUR
A1  - Lehrnbecher, T.
A1  - Poot, M.
A1  - Orscheschek, K.
A1  - Sebald, Walter
A1  - Feller, A. C.
A1  - Merz, H.
T1  - Interleukin 7 as interleukin 9 drives phytohemagglutinin-activated T cells through several cell cycles; no synergism between interleukin 7, interleukin 9 and interleukin 4
N2  - The effects of the interlenkins IL-7 and IL-9 on cell cycle progression were investigated by conventional [3H]thymidine incorporation and by the bivariate BrdU/Hoechst technique. 8oth IL· 7 and IL-9 drive phytohemagglutinin-activated T cells through more than one cell cycle, but IL-7 wasmorepotent on cell cycle progression than IL-9. Neither synergistic nor inhibitory effects were seen between various combinations of the lymphokines IL-7, IL-9 and IL-4 compared to each lymphokine alone. When T cells are activated with phytohemagglutinin for 3 days, all or most IL-4 responsive cells respond to IL-7 as weil, whereas only a part of IL-7 responders are IL-4 responders. In contrast, when T cells are activated with phytohemagglutinin for 7 days, the quantitative data of the cell cycle distribution soggest that the population of IL-7 responders is at least an overlapping, if not a real subset of the population of the IL-4 responders.
KW  - Biochemie
Y1  - 1994
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/5710
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-62438
ER  -