TY  - JOUR
A1  - Forconi, Mariko
A1  - Canapa, Adriana
A1  - Barucca, Marco
A1  - Biscotti, Maria A.
A1  - Capriglione, Teresa
A1  - Buonocore, Francesco
A1  - Fausto, Anna M.
A1  - Makapedua, Daisy M.
A1  - Pallavicini, Alberto
A1  - Gerdol, Marco
A1  - De Moro, Gianluca
A1  - Scapigliati, Giuseppe
A1  - Olmo, Ettore
A1  - Schartl, Manfred
T1  - Characterization of Sex Determination and Sex Differentiation Genes in Latimeria
T2  - PLoS ONE
N2  - Genes involved in sex determination and differentiation have been identified in mice, humans, chickens, reptiles, amphibians and teleost fishes. However, little is known of their functional conservation, and it is unclear whether there is a common set of genes shared by all vertebrates. Coelacanths, basal Sarcopterygians and unique "living fossils", could help establish an inventory of the ancestral genes involved in these important developmental processes and provide insights into their components. In this study 33 genes from the genome of Latimeria chalumnae and from the liver and testis transcriptomes of Latimeria menadoensis, implicated in sex determination and differentiation, were identified and characterized and their expression levels measured. Interesting findings were obtained for GSDF, previously identified only in teleosts and now characterized for the first time in the sarcopterygian lineage; FGF9, which is not found in teleosts; and DMRT1, whose expression in adult gonads has recently been related to maintenance of sexual identity. The gene repertoire and testis-specific gene expression documented in coelacanths demonstrate a greater similarity to modern fishes and point to unexpected changes in the gene regulatory network governing sexual development.
KW  - medaka fish
KW  - mullerian hormone AMH
KW  - DM-domain gene
KW  - oryzias latipes
KW  - monodelphis domestica
KW  - oreochromis niloticus
KW  - dimorphic expression
KW  - molecular mechanisms
KW  - genomic organization
KW  - regulatory regions
Y1  - 2013
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/13099
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-130995
VL  - 8
IS  - 4
ER  -