TY  - JOUR
A1  - Rak, Katrin
A1  - Hamm, Henning
A1  - Kerstan, Andreas
A1  - Kolb-Mäurer, Annette
A1  - Goebeler, Matthias
T1  - Severe and prolonged liver damage in pityriasis rubra pilaris treated with acitretin: a case report
T2  - SN Comprehensive Clinical Medicine
N2  - Acitretin is a systemic retinoid that is used in dermatology for treatment of various inflammatory and especially hyperkeratotic diseases. Elevation of liver enzymes may occur occasionally but normally resolves spontaneously, at the latest after termination of acitretin. However, it can very rarely develop into a life-threatening adverse event including drug-induced liver injury (DILI). A 45-year-old man with classical pityriasis rubra pilaris, a frequently severe, inflammatory skin disease, was started on acitretin. After a seemingly harmless elevation of transaminases, a few weeks after initiation of acitretin, the patient experienced a dramatic course of liver injury with hepatic jaundice though acitretin was stopped immediately. Eventually, laboratory values recovered upon high-dose oral prednisolone therapy. Prescribing physicians should keep in mind that acitretin might induce severe liver injury. Even after termination of acitretin laboratory values should be monitored for a while in order to recognize symptomless but harmful drug-induced liver injury in time.
KW  - acitretin
KW  - pityriasis rubra pilaris
KW  - drug-induced liver injury (DILI)
KW  - adverse event
Y1  - 2022
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/32398
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-323982
VL  - 4
IS  - 1
ER  -