TY  - JOUR
A1  - Raschig, Martina
A1  - Ramírez‐Zavala, Bernardo
A1  - Wiest, Johannes
A1  - Saedtler, Marco
A1  - Gutmann, Marcus
A1  - Holzgrabe, Ulrike
A1  - Morschhäuser, Joachim
A1  - Meinel, Lorenz
T1  - Azobenzene derivatives with activity against drug‐resistant Candida albicans and Candida auris
T2  - Archiv der Pharmazie
N2  - Increasing resistance against antimycotic drugs challenges anti‐infective therapies today and contributes to the mortality of infections by drug‐resistant Candida species and strains. Therefore, novel antifungal agents are needed. A promising approach in developing new drugs is using naturally occurring molecules as lead structures. In this work, 4,4'‐dihydroxyazobenzene, a compound structurally related to antifungal stilbene derivatives and present in Agaricus xanthodermus (yellow stainer), served as a starting point for the synthesis of five azobenzene derivatives. These compounds prevented the growth of both fluconazole‐susceptible and fluconazole‐resistant Candida albicans and Candida auris strains. Further in vivo studies are required to confirm the potential therapeutic value of these compounds.
KW  - antifungal drug
KW  - azobenzenes
KW  - Candida auris
KW  - Candida albicans
Y1  - 2023
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/31229
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-312295
VL  - 356
IS  - 2
ER  -