TY  - JOUR
A1  - Tacke, Reinhold
A1  - Linoh, Haryanto
A1  - Attar-Bashi, Moayad T.
A1  - Sheldrick, William S.
A1  - Ernst, Ludger
A1  - Niedner, Roland
A1  - Frohnecke, Joachim
T1  - Sila-Pharmaka, 26. Mitt. [1] Darstellung und Eigenschaften potentiell curarewirksamer Silicium-Verbindungen, III
T1  - Sila-Pharmaca, 26th Communication [1] Preparation and Properties of Silicon Compounds with Potential Curare-Like Activity, III
T2  - Zeitschrift für Naturforschung B
N2  - The potentially curare-like silicon compounds 8a- 8f were synthesized and investigated with respect to their structure-activity relationships. The conformations of the compounds in the solid state and in solution were studied by X-ray diffraction analysis (8a- 8e) and IR NMR spectroscopy (8a- 8f), respectively. The muscle relaxing properties of 8a- 8f were investigated on the mouse. The observed structure-activity relationships are not in accordance with the classical "14 Å model" for neuromuscular blocking agents.
KW  - structure-activity relationships
KW  - X-ray
KW  - curare-lik activity
KW  - silicon compounds
KW  - conformational anaylses
Y1  - 1982
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/12840
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-128402
VL  - 37
IS  - 11
ER  -