TY  - JOUR
A1  - Koeniger, Tobias
A1  - Kuerten, Stefanie
T1  - Splitting the "unsplittable": Dissecting resident and infiltrating macrophages in experimental autoimmune encephalomyelitis
T2  - International Journal of Molecular Sciences
N2  - Macrophages predominate the inflammatory landscape within multiple sclerosis (MS) lesions, not only regarding cellularity but also with respect to the diverse functions this cell fraction provides during disease progression and remission. Researchers have been well aware of the fact that the macrophage pool during central nervous system (CNS) autoimmunity consists of a mixture of myeloid cells. Yet, separating these populations to define their unique contribution to disease pathology has long been challenging due to their similar marker expression. Sophisticated lineage tracing approaches as well as comprehensive transcriptome analysis have elevated our insight into macrophage biology to a new level enabling scientists to dissect the roles of resident (microglia and non-parenchymal macrophages) and infiltrating macrophages with unprecedented precision. To do so in an accurate way, researchers have to know their toolbox, which has been filled with diverse, discriminating approaches from decades of studying neuroinflammation in animal models. Every method has its own strengths and weaknesses, which will be addressed in this review. The focus will be on tools to manipulate and/or identify different macrophage subgroups within the injured murine CNS.
KW  - CNS
KW  - distinction
KW  - experimental autoimmune encephalomyelitis
KW  - inflammation
KW  - macrophages
KW  - markers
KW  - microglia
KW  - monocytes
Y1  - 2017
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/28506
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-285067
SN  - 1422-0067
VL  - 18
IS  - 10
ER  -