TY  - JOUR
A1  - Zhou, Xiang
A1  - Ruckdeschel, Anna
A1  - Peter, Jessica
A1  - Böckle, David
A1  - Hornburger, Hannah
A1  - Danhof, Sophia
A1  - Steinhardt, Maximilian Johannes
A1  - Heimeshoff, Larissa
A1  - Einsele, Hermann
A1  - Kortüm, Klaus Martin
A1  - Rasche, Leo
T1  - Salvage therapy with "Dara-KDT-P(A)CE" in heavily pretreated, high-risk, proliferative, relapsed/refractory multiple myeloma
T2  - Hematological Oncology
N2  - The multi-agent therapy “VDT-PACE” represents an established regimen in relapsed/refractory multiple myeloma (RRMM). Here, we report on our experience with a “modified VDT-PACE” incorporating new generation anti-MM agents daratumumab and carfilzomib (“Dara-KDT-P(A)CE”). We retrospectively analyzed 38 patients with RRMM treated with “Dara-KDT-P(A)CE”. The median age was 62 (range 45–82) years, and the patients were heavily pretreated with a median of 5 (range 2–12) prior lines of therapy. Twenty-one (55%) patients suffered from penta-refractory MM. High-risk cytogenetics was present in 31 (81%) patients. The patients received a median of 2 (range 1–10) cycles of this therapy, and the overall response rate (ORR) was 70%. Patients with penta-refractory MM and high-risk cytogenetics showed similar ORR of 65% and 79%, respectively. The median progression-free survival (PFS) and overall survival were 4.1 (95% CI 2.7–5.4) and 8.4 (95% CI 6.7–10.0) months, respectively. Patients with lactate dehydrogenase >250 IU/L showed significantly shorter PFS in comparison with others patients (p = 0.006). We used this regimen as bridging therapy prior to chimeric antigen receptor T-cell infusion in four patients. In conclusion, “Dara-KDT-P(A)CE” is an effective salvage therapy for patients with heavily pretreated, multi-refractory, high-risk RRMM lacking alternative options.
KW  - Dara-KDT-P(A)CE
KW  - multiple myeloma
KW  - refractory
KW  - salvage
Y1  - 2022
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/25749
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-257495
VL  - 40
IS  - 2
ER  -