TY  - JOUR
A1  - Engert, Jonas
A1  - Doll, Julia
A1  - Vona, Barbara
A1  - Ehret Kasemo, Totta
A1  - Spahn, Bjoern
A1  - Hagen, Rudolf
A1  - Rak, Kristen
A1  - Voelker, Johannes
T1  - mRNA abundance of neurogenic factors correlates with hearing capacity in auditory brainstem nuclei of the rat
T2  - Life
N2  - Neural stem cells (NSCs) have previously been described up to the adult stage in the rat cochlear nucleus (CN). A decreasing neurogenic potential was observed with critical changes around hearing onset. A better understanding of molecular factors affecting NSCs and neurogenesis is of interest as they represent potential targets to treat the cause of neurologically based hearing disorders. The role of genes affecting NSC development and neurogenesis in CN over time on hearing capacity has remained unclear. This study investigated the mRNA abundance of genes influencing NSCs and neurogenesis in rats’ CN over time. The CN of rats on postnatal days 6, 12, and 24 were examined. Real-time quantitative polymerase chain reaction arrays were used to compare mRNA levels of 84 genes relevant to NSCs and neurogenesis. Age- and hearing-specific patterns of changes in mRNA abundance of neurogenically relevant genes were detected in the rat CN. Additionally, crucial neurogenic factors with significant and relevant influence on neurogenesis were identified. The results of this work should contribute to a better understanding of the molecular mechanisms underlying the neurogenesis of the auditory pathway.
KW  - real-time PCR
KW  - auditory pathway
KW  - neurogenesis
KW  - cochlear nucleus
Y1  - 2023
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/35739
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-357392
SN  - 2075-1729
VL  - 13
IS  - 9
ER  -