TY  - JOUR
A1  - Hartung, Andreas
A1  - Seufert, Florian
A1  - Berges, Carsten
A1  - Gessner, Viktoria H.
A1  - Holzgrabe, Ulrike
T1  - One-Pot Ugi/Aza-Michael Synthesis of Highly Substituted 2,5-Diketopiperazines with Anti-Proliferative Properties
T2  - Molecules
N2  - The well-known Ugi reaction of aldehydes with amines, carboxylic acids and isocyanides leads to the formation of acyclic alpha-acylaminocarboxamides. Replacement of the carboxylic acid derivatives with beta-acyl substituted acrylic acids gives access to highly substituted 2,5-diketopiperazines in one single reaction-step without additives or complex reaction procedures. The obtained diketopiperazines show anti-proliferative effects on activated T cells and represent therefore potential candidates for targeting unwanted T cell-mediated immune responses.
KW  - multicomponent Ugi-type reaction
KW  - intramolecular Michael addition
KW  - strategy
KW  - derivates
KW  - diketopiperazines
KW  - chemistry
KW  - T cell
KW  - 2,5-diketopiperazines
KW  - anti-proliferative effects
Y1  - 2012
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/13042
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-130423
VL  - 17
IS  - 12
ER  -