TY  - JOUR
A1  - Klotz, Karl-Norbert
A1  - Jesaitis, A. J.
T1  - Neutrophil chemoattractant receptors and the membrane skeleton
N2  - Signal transduction via receptors for N-formylmethionyl peptide chemoattractants (FPR) on human neutrophils is a highly regulated process which involves participation of cytoskeletal elements. Evidence exists suggesting that the cytoskeleton and/or the membrane skeleton controls the distributJon of FPR in the plane of the plasma membrane, thus controlling the accessibility of FPR to different proteins in functionally distinct domains. In desensitized cells, FPR are restricted todomains which are depleted of G proteins but enriched in cytoskeletal proteins such as actin and fodrin. Thus, the G protein signal transduction partners of FPR become inaccessible to the agonist-occupied receptor, preventing cell activation. The mechanism of interaction of FPR with the membrane skeleton is poorly understood but evidence is accumulating that suggests a direct binding of FPR (and other receptors) to cytoskeletal proteins such as actin.
KW  - Toxikologie
Y1  - 1994
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/5401
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-60471
ER  -