TY  - JOUR
A1  - Kopf, Juliane
A1  - Glöckner, Stefan
A1  - Althen, Heike
A1  - Cevada, Thais
A1  - Schecklmann, Martin
A1  - Dresler, Thomas
A1  - Kittel-Schneider, Sarah
A1  - Reif, Andreas
T1  - Neural responses to a working memory task in acute depressed and remitted phases in bipolar patients
T2  - Brain Sciences
N2  - (1) Cognitive impairments such as working memory (WM) deficits are amongst the most common dysfunctions characterizing bipolar disorder (BD) patients, severely contributing to functional impairment. We aimed to investigate WM performance and associated brain activation during the acute phase of BD and to observe changes in the same patients during remission. (2) Frontal brain activation was recorded using functional near-infrared spectroscopy (fNIRS) during n-back task conditions (one-back, two-back and three-back) in BD patients in their acute depressive (n = 32) and remitted (n = 15) phases as well as in healthy controls (n = 30). (3) Comparison of BD patients during their acute phase with controls showed a trend (p = 0.08) towards lower dorsolateral prefrontal cortex (dlPFC) activation. In the remitted phase, BD patients showed lower dlPFC and ventrolateral prefrontal cortex (vlPFC) activation (p = 0.02) compared to controls. No difference in dlPFC and vlPFC activation between BD patients’ phases was found. (4) Our results showed decreased working memory performance in BD patients during the working memory task in the acute phase of disease. Working memory performance improved in the remitted phase of the disease but was still particularly attenuated for the more demanding conditions.
KW  - verbal n-back
KW  - fNIRS
KW  - prefrontal cortex
KW  - cognitive deficits
KW  - bipolar disorder
KW  - remitted/acute phase
Y1  - 2023
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/31350
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-313509
SN  - 2076-3425
VL  - 13
IS  - 5
ER  -