TY  - JOUR
A1  - Isaias, Ioannis Ugo
A1  - Spiegel, Jörg
A1  - Brumberg, Joachim
A1  - Cosgrove, Kelly P.
A1  - Marotta, Giorgio
A1  - Oishi, Naoya
A1  - Higuchi, Takahiro
A1  - Küsters, Sebastian
A1  - Schiller, Markus
A1  - Dillmann, Ulrich
A1  - van Dyck, Christopher H.
A1  - Buck, Andreas
A1  - Herrmann, Ken
A1  - Schloegl, Susanne
A1  - Volkmann, Jens
A1  - Lassmann, Michael
A1  - Fassbender, Klaus
A1  - Lorenz, Reinhard
A1  - Samnick, Samuel
T1  - Nicotinic acetylcholine receptor density in cognitively intact subjects at an early stage of Parkinson's disease
T2  - Frontiers in Aging Neuroscience
N2  - We investigated in vivo brain nicotinic acetylcholine receptor (nAChR) distribution in cognitively intact subjects with Parkinson's disease (PD) at an early stage of the disease. Fourteen patients and 13 healthy subjects were imaged with single photon emission computed tomography and the radiotracer 5-[(123)I]iodo-3-[2(S)-2-azetidinylmethoxy]pyridine ([(123)I]5IA). Patients were selected according to several criteria, including short duration of motor signs (<7 years) and normal scores at an extensive neuropsychological evaluation. In PD patients, nAChR density was significantly higher in the putamen, the insular cortex and the supplementary motor area and lower in the caudate nucleus, the orbitofrontal cortex, and the middle temporal gyrus. Disease duration positively correlated with nAChR density in the putamen ipsilateral (ρ = 0.56, p < 0.05) but not contralateral (ρ = 0.49, p = 0.07) to the clinically most affected hemibody. We observed, for the first time in vivo, higher nAChR density in brain regions of the motor and limbic basal ganglia circuits of subjects with PD. Our findings support the notion of an up-regulated cholinergic activity at the striatal and possibly cortical level in cognitively intact PD patients at an early stage of disease.
KW  - nicotinic receptors
KW  - Parkinson disease
KW  - 5IA-SPECT
KW  - dopamine acetylcholine
KW  - cognitive decline
Y1  - 2014
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/11935
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-119351
VL  - 6
ER  -