TY  - JOUR
A1  - Marre, R.
A1  - Hacker, Jörg
A1  - Wood, G.
A1  - Schmidt, G.
T1  - Oral vaccination of rats with live avirulent Salmonella derivatives expressing adhesive fimbrial agents of uropathogenic Escherichia coli
N2  - The avirulent Salmonella typhimurium F885 was transformed with a plasmid carrying the cloned S fimbriae genes of a uropathogenic Escherichia coli. The resulting transformant (F885-1) produced efficiently E. coli S fimbriae and was used for live oral vaccination of rats. For comparison rats were immunized subcutaneously with isolated S fimbriae. Both routes of vaccination resulted in a significant lgG antibody response to S fimbriae. In addition live oral vaccination induced a serum lgA response against S fimbriae. After transurethral infection of rats with a S fimbriae producing E. coli a 10-fold reduction of bacterial counts in the kidney was observed in rats orally vaccinated with F885-1 as compared to unvaccinated controls. This study suggests that the avirulent Salmonella F885 may be used as a fimbrial antigen carrier for oral vaccination against renal infections.
KW  - Infektionsbiologie
KW  - Avirulent Salmonella
KW  - S-Fimbriae
KW  - Uropatbcgenie E. coli
Y1  - 1989
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/5267
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-59559
ER  -