TY  - JOUR
A1  - Prasse, Tobias
A1  - Stratos, Ioannis
A1  - Niehoff, Anja
A1  - Christ, Hildegard
A1  - Heck, Vincent
A1  - Meyer, Carolin
A1  - Mittlmeier, Thomas
T1  - Bisphenol A-related effects on bone morphology and biomechanical properties in an animal model
T2  - Toxics
N2  - Bisphenol A (BPA), which is contained in numerous plastic products, is known to act as an endocrine-disruptive, toxic, and carcinogenic chemical. This experimental series sought to determine the influence of BPA exposure on the femoral bone architecture and biomechanical properties of male and female Wistar rats. BPA was applied subcutaneously by using osmotic pumps. After 12 weeks, the bones were analyzed by micro-computed tomography (micro-CT) and a three-point bending test. Comparing the female low- and high-dose groups, a significantly greater marrow area (p = 0.047) was identified in the group exposed to a higher BPA concentration. In addition, the trabecular number tended to be higher in the female high-dose group when compared to the low-dose group (p > 0.05). The area moment of inertia also tended to be higher in the male high-dose group when compared to the male low-dose group (p > 0.05). Considering our results, BPA-related effects on the bone morphology in female Wistar rats are osteoanabolic after high-dose exposure, while, in male rats, a tendency toward negative effects on the bone morphology in terms of a reduced cross-sectional cortical area and total area could be demonstrated.
KW  - bisphenol A
KW  - endocrine disruption
KW  - bone morphology
KW  - micro-computed tomography
KW  - mechanical property
KW  - three-point bending
Y1  - 2022
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/26221
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-262216
SN  - 2305-6304
VL  - 10
IS  - 2
ER  -