TY  - JOUR
A1  - Liedert, Astrid
A1  - Nemitz, Claudia
A1  - Haffner-Luntzer, Melanie
A1  - Schick, Fabian
A1  - Jakob, Franz
A1  - Ignatius, Anita
T1  - Effects of estrogen receptor and Wnt signaling activation on mechanically induced bone formation in a mouse model of postmenopausal bone loss
T2  - International Journal of Molecular Sciences
N2  - In the adult skeleton, bone remodeling is required to replace damaged bone and functionally adapt bone mass and structure according to the mechanical requirements. It is regulated by multiple endocrine and paracrine factors, including hormones and growth factors, which interact in a coordinated manner. Because the response of bone to mechanical signals is dependent on functional estrogen receptor (ER) and Wnt/β-catenin signaling and is impaired in postmenopausal osteoporosis by estrogen deficiency, it is of paramount importance to elucidate the underlying mechanisms as a basis for the development of new strategies in the treatment of osteoporosis. The present study aimed to investigate the effectiveness of the activation of the ligand-dependent ER and the Wnt/β-catenin signal transduction pathways on mechanically induced bone formation using ovariectomized mice as a model of postmenopausal bone loss. We demonstrated that both pathways interact in the regulation of bone mass adaption in response to mechanical loading and that the activation of Wnt/β-catenin signaling considerably increased mechanically induced bone formation, whereas the effects of estrogen treatment strictly depended on the estrogen status in the mice.
KW  - bone remodeling
KW  - mechanotransduction
KW  - ER signaling
KW  - Wnt/β-catenin signaling
KW  - ovariectomy
Y1  - 2020
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/28548
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-285487
SN  - 1422-0067
VL  - 21
IS  - 21
ER  -