TY  - JOUR
A1  - Willems, Suzanne
A1  - Detta, Elena
A1  - Baldini, Lorenzo
A1  - Tietz, Deniz
A1  - Trabocchi, Andrea
A1  - Brunschweiger, Andreas
T1  - Diversifying DNA-tagged amines by isocyanide multicomponent reactions for DNA-encoded library synthesis
T2  - ACS Omega
N2  - In DNA-encoded library synthesis, amine-substituted building blocks are prevalent. We explored isocyanide multicomponent reactions to diversify DNA-tagged amines and reported the Ugi-azide reaction with high yields and a good substrate scope. In addition, the Ugi-aza-Wittig reaction and the Ugi-4-center-3-component reaction, which used bifunctional carboxylic acids to provide lactams, were explored. Five-, six-, and seven-membered lactams were synthesized from solid support-coupled DNA-tagged amines and bifunctional building blocks, providing access to structurally diverse scaffolds.
KW  - DNA-tagged amines
KW  - DNA-encoded library synthesis
KW  - isocyanide multicomponent reactions
KW  - Ugi-azide reaction
KW  - lactams
Y1  - 2024
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/34980
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-349809
SN  - 2470-1343
VL  - 9
IS  - 7
ER  -