TY  - JOUR
A1  - Lisowski, Dominik
A1  - Hartrampf, Philipp E.
A1  - Hasenauer, Natalie
A1  - Nickl, Vera
A1  - Monoranu, Camelia-Maria
A1  - Tamihardja, Jörg
T1  - Complete loss of E-cadherin expression in a rare case of metastatic malignant meningioma: a case report
T2  - BMC Neurology
N2  - Background
Hematogenous tumor spread of malignant meningiomas occurs very rarely but is associated with very poor prognosis.

Case presentation
We report an unusual case of a patient with a malignant meningioma who developed multiple metastases in bones, lungs and liver after initial complete resection of the primary tumor. After partial hepatic resection, specimens were histologically analyzed, and a complete loss of E-cadherin adhesion molecules was found. No oncogenic target mutations were found. The patient received a combination of conventional radiotherapy and peptide receptor radionuclide therapy (PRRT). Due to aggressive tumor behavior and rapid spread of metastases, the patient deceased after initiation of treatment.

Conclusions
E-cadherin downregulation is associated with a higher probability of tumor invasion and distant metastasis formation in malignant meningioma. Up to now, the efficacy of systemic therapy, including PRRT, is very limited in malignant meningioma patients.
KW  - beta-catenin
KW  - E-cadherin
KW  - meningioma
KW  - peptide receptor radionuclide therapy (PRRT)
KW  - radiotherapy
Y1  - 2023
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/35799
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-357996
VL  - 23
ER  -