TY  - JOUR
A1  - Stopper, Helga
A1  - Metzler, M.
T1  - Carcinogenic oestrogens induce respiration deficiency mutation in yeast
N2  - In addition to hormonal activity, genetic darnage has been proposed as an important factor in oestrogen-mediated carcinogenesis. However, as short-term tests for oestrogens usually fail to show DNA mutations, lesions other than dassie nuclear DNA mutation have to be considered. Oestrogeninduced mitochondrial darnage was studied in the yeast Saccharomyces cerevisiae. Stilbene-type, but not steroidal, oestrogens were found to induce respiration-dcficient petite mutation. The effect was inversely correlated with cytotoxicity and required aromatic hydroxyl groups at the stilbene molecule. It only occurred under growth conditions and apparently was not due to the A TPase inhibitory qualities of stilbene oestrogens. Other studies have shown that petite mutation clones, which can be induced by a variety of substances, contain altered mitochondrial DNA. The mechanism of petite mutation induction might be important in tumorigenesis by also acting on nuclear DNA or facilitating carcinogenesis by disturbance of mitochondrial function.
KW  - Toxikologie
Y1  - 1991
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/6030
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-63466
ER  -