TY  - JOUR
A1  - Moll, Heidrun
A1  - Mitchell, Graham F.
A1  - McConville, Malcom J.
A1  - Handman, Emanuela
T1  - Evidence for T cell recognition in mice of a purified lipophosphoglycan from Leishmania major
N2  - We have previously reported that a Leishmania major lipophosphoglycan (LPG), given with killed Corynebacterium parvum as an adjuvant, can vaccinate mice against cutaneous leishmaniasis. In order to analyze whetber T cells are able to recognize this important parasite antigen, we have studied both humoral and cellular immune responses to L. major LPG that bad been isolated from promastigotes by sequential solvent extraction and bydrophobic chromatography. The data sbow that immunization of mice with highly purified LPG induced an increase in frequency of L. major-reactive T cells and the production of immunoglobulin G antibodies to LPG. Furthermore, genetically resistant mice infected with L. major were able to develop a specific delayed-type hypersensitivity response in the ear to L. major LPG. These findings strongly suggest that T cells can recognize and respond to glycolipid antigens, in this case a bost-protective Leishmania LPG, even though such antigens appear not to be potent T-cell stimulators in mice.
KW  - Biologie
Y1  - 1989
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/5104
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-61288
ER  -