TY  - JOUR
A1  - Röhrich, Christian Rene
A1  - Ngwa, Che Julius
A1  - Wiesner, Jochen
A1  - Schmidtberg, Henrike
A1  - Degenkolb, Thomas
A1  - Kollewe, Christian
A1  - Fischer, Rainer
A1  - Pradel, Gabriele
A1  - Vilcinskas, Andreas
T1  - Harmonine, a defence compound from the harlequin ladybird, inhibits mycobacterial growth and demonstrates multi-stage antimalarial activity
T2  - Biology Letters
N2  - The harlequin ladybird beetle Harmonia axyridis has been introduced in many countries as a biological control agent, but has become an invasive species threatening the biodiversity of native ladybirds. Its invasive success has been attributed to its vigorous resistance against diverse pathogens. This study demonstrates that harmonine ((17R,9Z)-1,17-diaminooctadec-9-ene), which is present in H. axyridis haemolymph, displays broad-spectrum antimicrobial activity that includes human pathogens. Antibacterial activity is most pronounced against fast-growing mycobacteria and Mycobacterium tuberculosis, and the growth of both chloroquine-sensitive and -resistant Plasmodium falciparum strains is inhibited. Harmonine displays gametocytocidal activity, and inhibits the exflagellation of microgametocytes and zygote formation. In an Anopheles stephensi mosquito feeding model, harmonine displays transmission-blocking activity.
KW  - insect immunity
KW  - antimicrobial activity
KW  - harmonine
KW  - harmonia axyridis
Y1  - 2012
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/12707
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-127079
VL  - 8
ER  -