TY  - JOUR
A1  - Oehler, Beatrice
A1  - Brack, Alexander
A1  - Blum, Robert
A1  - Rittner, Heike L.
T1  - Pain Control by Targeting Oxidized Phospholipids: Functions, Mechanisms, Perspectives
T2  - Frontiers in Endocrinology
N2  - Within the lipidome oxidized phospholipids (OxPL) form a class of chemically highly reactive metabolites. OxPL are acutely produced in inflamed tissue and act as endogenous, proalgesic (pain-inducing) metabolites. They excite sensory, nociceptive neurons by activating transient receptor potential ion channels, specifically TRPA1 and TRPV1. Under inflammatory conditions, OxPL-mediated receptor potentials even potentiate the action potential firing rate of nociceptors. Targeting OxPL with D-4F, an apolipoprotein A-I mimetic peptide or antibodies like E06, specifically binding oxidized headgroups of phospholipids, can be used to control acute, inflammatory pain syndromes, at least in rodents. With a focus on proalgesic specificities of OxPL, this article discusses, how targeting defined substances of the epilipidome can contribute to mechanism-based therapies against primary and secondary chronic inflammatory or possibly also neuropathic pain.
KW  - oxidized phospholipids
KW  - TRP channel
KW  - ion channel
KW  - analgesia
KW  - pain therapy
KW  - nociception
KW  - therapeutic antibody
KW  - mimetic peptide
Y1  - 2021
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/22343
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-223432
SN  - 1664-2392
VL  - 11
ER  -