TY  - JOUR
A1  - Janjetovic, Snjezana
A1  - Lohneis, Philipp
A1  - Nogai, Axel
A1  - Balci, Derya
A1  - Rasche, Leo
A1  - Jähne, Doris
A1  - Bokemeyer, Carsten
A1  - Schilling, Georgia
A1  - Blau, Igor Wolfgang
A1  - Schmidt-Hieber, Martin
T1  - Clinical and biological characteristics of medullary and extramedullary plasma cell dyscrasias
T2  - Biology
N2  - Background: Extramedullary plasma cell (PC) disorders may occur as extramedullary disease in multiple myeloma (MM-EMD) or as primary extramedullary plasmocytoma (pEMP)/solitary osseous plasmocytoma (SOP). In this study, we aimed to obtain insights into the molecular mechanisms of extramedullary spread of clonal PC. Methods: Clinical and biological characteristics of 87 patients with MM-EMD (n = 49), pEMP/SOP (n = 20) and classical MM (n = 18) were analyzed by using immunohistochemistry (CXCR4, CD31, CD44 and CD81 staining) and cytoplasmic immunoglobulin staining combined with fluorescence in situ hybridization (cIg-FISH). Results: High expression of CD44, a cell-surface glycoprotein involved in cell-cell interactions, was significantly enriched in MM-EMD (90%) vs. pEMP/SOP (27%) or classical MM (33%) (p < 0.001). In addition, 1q21 amplification by clonal PC occurred at a similar frequency of MM-EMD (33%), pEMP/SOP (57%) and classical MM (44%). Conversely, del(17p13), t(4;14) and t(14;16) were completely absent in pEMP/SOP. Besides this, 1q21 amplification was identified in 64% of not paraskeletal samples from MM-EMD or pEMP compared to 9% of SOP or paraskeletal MM-EMD/pEMP and 44% of classical MM samples, respectively (p = 0.02). Conclusion: Expression of molecules involved in homing and cytogenetic aberrations differ between MM with or without EMD and pEMP/SOP.
KW  - plasma cell disorder
KW  - multiple myeloma
KW  - extramedullary
KW  - immunohistochemistry
KW  - cytogenetics
Y1  - 2021
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/24259
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-242592
SN  - 2079-7737
VL  - 10
IS  - 7
ER  -