TY  - JOUR
A1  - de Jong, Simone
A1  - Diniz, Mateus Jose Abdalla
A1  - Saloma, Andiara
A1  - Gadelha, Ary
A1  - Santoro, Marcos L.
A1  - Ota, Vanessa K.
A1  - Noto, Cristiano
A1  - Curtis, Charles
A1  - Newhouse, Stephen J.
A1  - Patel, Hamel
A1  - Hall, Lynsey S.
A1  - O'Reilly, Paul F.
A1  - Belangero, Sintia I.
A1  - Bressan, Rodrigo A.
A1  - Breen, Gerome
T1  - Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder
T2  - Communications Biology
N2  - Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores to also highlight patterns of common genetic risk. We analyze polygenic risk scores for psychiatric disorders in a large pedigree (n ~ 260) in which 30% of family members suffer from major depressive disorder or bipolar disorder. Studying patterns of assortative mating and anticipation, it appears increased polygenic risk is contributed by affected individuals who married into the family, resulting in an increasing genetic risk over generations. This may explain the observation of anticipation in mood disorders, whereby onset is earlier and the severity increases over the generations of a family. Joint analyses of rare and common variation may be a powerful way to understand the familial genetics of psychiatric disorders.
KW  - bipolar disorder
KW  - depression
KW  - genetic association study
KW  - genetic linkage study
Y1  - 2018
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/22362
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-223622
VL  - 1
ER  -