TY  - JOUR
A1  - Gulve, Nitish
A1  - Frank, Celina
A1  - Klepsch, Maximilian
A1  - Prusty, Bhupesh K.
T1  - Chromosomal integration of HHV-6A during non-productive viral infection
T2  - Scientific Reports
N2  - Human herpesvirus 6A (HHV-6A) and 6B (HHV-6B) are two different species of betaherpesviruses that integrate into sub-telomeric ends of human chromosomes, for which different prevalence rates of integration have been reported. It has been demonstrated that integrated viral genome is stable and is fully retained. However, study of chromosomally integrated viral genome in individuals carrying inherited HHV-6 (iciHHV-6) showed unexpected number of viral DR copies. Hence, we created an in vitro infection model and studied retention of full or partial viral genome over a period of time. We observed an exceptional event where cells retained viral direct repeats (DRs) alone in the absence of the full viral genome. Finally, we found evidence for non-telomeric integration of HHV-6A DR in both cultured cells and in an iciHHV-6 individual. Our results shed light on several novel features of HHV-6A chromosomal integration and provide valuable information for future screening techniques.
KW  - herpes virus
KW  - infectious-disease diagnostics
Y1  - 2017
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/15811
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-158117
VL  - 7
IS  - 512
ER  -