TY  - JOUR
A1  - Selcho, Mareike
A1  - Millán, Carola
A1  - Palacios-Muñoz, Angelina
A1  - Ruf, Franziska
A1  - Ubillo, Lilian
A1  - Chen, Jiangtian
A1  - Bergmann, Gregor
A1  - Ito, Chihiro
A1  - Silva, Valeria
A1  - Wegener, Christian
A1  - Ewer, John
T1  - Central and peripheral clocks are coupled by a neuropeptide pathway in Drosophila
T2  - Nature Communications
N2  - Animal circadian clocks consist of central and peripheral pacemakers, which are coordinated to produce daily rhythms in physiology and behaviour. Despite its importance for optimal performance and health, the mechanism of clock coordination is poorly understood. Here we dissect the pathway through which the circadian clock of Drosophila imposes daily rhythmicity to the pattern of adult emergence. Rhythmicity depends on the coupling between the brain clock and a peripheral clock in the prothoracic gland (PG), which produces the steroid hormone, ecdysone. Time information from the central clock is transmitted via the neuropeptide, sNPF, to non-clock neurons that produce the neuropeptide, PTTH. These secretory neurons then forward time information to the PG clock. We also show that the central clock exerts a dominant role on the peripheral clock. This use of two coupled clocks could serve as a paradigm to understand how daily steroid hormone rhythms are generated in animals.
KW  - circadian clock
KW  - Drosophila
KW  - neuropeptide pathway
KW  - peripheral clocks
KW  - central clocks
Y1  - 2017
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/17083
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-170831
VL  - 8
IS  - 15563
ER  -