TY  - JOUR
A1  - Baur, Stefanie
A1  - Rautenberg, Maren
A1  - Faulstich, Manuela
A1  - Grau, Timo
A1  - Severin, Yannik
A1  - Unger, Clemens
A1  - Hoffmann, Wolfgang H.
A1  - Rudel, Thomas
A1  - Autenrieth, Ingo B.
A1  - Weidenmaier, Christopher
T1  - A Nasal Epithelial Receptor for Staphylococcus aureus WTA Governs Adhesion to Epithelial Cells and Modulates Nasal Colonization
T2  - PLOS PATHOGENS
N2  - Nasal colonization is a major risk factor for S. aureus infections. The mechanisms responsible for colonization are still not well understood and involve several factors on the host and the bacterial side. One key factor is the cell wall teichoic acid (WTA) of S. aureus, which governs direct interactions with nasal epithelial surfaces. We report here the first receptor for the cell wall glycopolymer WTA on nasal epithelial cells. In several assay systems this type F-scavenger receptor, termed SREC-I, bound WTA in a charge dependent manner and mediated adhesion to nasal epithelial cells in vitro. The impact of WTA and SREC-I interaction on epithelial adhesion was especially pronounced under shear stress, which resembles the conditions found in the nasal cavity. Most importantly, we demonstrate here a key role of the WTA-receptor interaction in a cotton rat model of nasal colonization. When we inhibited WTA mediated adhesion with a SREC-I antibody, nasal colonization in the animal model was strongly reduced at the early onset of colonization. More importantly, colonization stayed low over an extended period of 6 days. Therefore we propose targeting of this glycopolymer-receptor interaction as a novel strategy to prevent or control S. aureus nasal colonization.
KW  - SREC-I
KW  - clumping factor-B
KW  - scavender receptor
KW  - teichoic acids
KW  - surface proteins
KW  - cotton rats
KW  - carriage
KW  - determinant
KW  - infections
KW  - expression
Y1  - 2014
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/11628
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-116280
SN  - 1553-7374
VL  - 10
IS  - 5
ER  -