TY  - JOUR
A1  - Hampf, Chantal
A1  - Scherf-Clavel, Maike
A1  - Weiß, Carolin
A1  - Klüpfel, Catherina
A1  - Stonawski, Saskia
A1  - Hommers, Leif
A1  - Lichter, Katharina
A1  - Erhardt-Lehmann, Angelika
A1  - Unterecker, Stefan
A1  - Domschke, Katharina
A1  - Kittel-Schneider, Sarah
A1  - Menke, Andreas
A1  - Deckert, Jürgen
A1  - Weber, Heike
T1  - Effects of anxious depression on antidepressant treatment response
T2  - International Journal of Molecular Sciences
N2  - Anxious depression represents a subtype of major depressive disorder and is associated with increased suicidality, severity, chronicity and lower treatment response. Only a few studies have investigated the differences between anxious depressed (aMDD) and non-anxious depressed (naMDD) patients regarding treatment dosage, serum-concentration and drug-specific treatment response. In our naturalistic and prospective study, we investigated whether the effectiveness of therapy including antidepressants (SSRI, SNRI, NaSSA, tricyclics and combinations) in aMDD patients differs significantly from that in naMDD patients. In a sample of 346 patients, we calculated the anxiety somatization factor (ASF) and defined treatment response as a reduction (≥50%) in the Hamilton Depression Rating Scale (HDRS)-21 score after 7 weeks of pharmacological treatment. We did not observe an association between therapy response and the baseline ASF-scores, or differences in therapy outcomes between aMDD and naMDD patients. However, non-responders had higher ASF-scores, and at week 7 aMDD patients displayed a worse therapy outcome than naMDD patients. In subgroup analyses for different antidepressant drugs, venlafaxine-treated aMDD patients showed a significantly worse outcome at week 7. Future prospective, randomized-controlled studies should address the question of a worse therapy outcome in aMDD patients for different psychopharmaceuticals individually.
KW  - pharmacotherapy
KW  - depressive disorder
KW  - anxious depression
KW  - anxiety
KW  - therapy response
Y1  - 2023
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/35580
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-355801
SN  - 1422-0067
VL  - 24
IS  - 24
ER  -