TY  - INPR
A1  - Bartfeld, Sina
T1  - Modeling infectious diseases and host-microbe interactions in gastrointestinal organoids
T2  - Developmental Biology
N2  - Advances in stem cell research have allowed the development of 3-dimensional (3D) primary cell cultures termed organoid cultures, as they closely mimic the in vivo organization of different cell lineages. Bridging the gap between 2-dimensional (2D) monotypic cancer cell lines and whole organisms, organoids are now widely applied to model development and disease. Organoids hold immense promise for addressing novel questions in host-microbe interactions, infectious diseases and the resulting inflammatory conditions. Researchers have started to use organoids for modeling infection with pathogens, such as Helicobacter pylori or Salmonella enteritica, gut- microbiota interactions and inflammatory bowel disease. Future studies will broaden the spectrum of microbes used and continue to establish organoids as a standard model for human host-microbial interactions. Moreover, they will increasingly exploit the unique advantages of organoids, for example to address patient-specific responses to microbes.
KW  - gastrointestinal disease
KW  - salmonella
KW  - microbiota
KW  - inflammatory bowel disease
KW  - organoid culture
KW  - helicobacter
KW  - rotavirus
KW  - norovirus
Y1  - 2016
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/13878
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-138788
UR  - http://www.sciencedirect.com/science/article/pii/S0012160616304602
SN  - 0012-1606
N1  - This is the accepted version of the following article: Bartfeld, Sina, Modeling infectious diseases and host-microbe interactions in gastrointestinal organoids, Developmental Biology, 2016, 420, 2, 262-270. http://dx.doi.org/10.1016/j.ydbio.2016.09.014
ER  -