TY  - JOUR
A1  - Rowinska, Zuzanna
A1  - Gorressen, Simone
A1  - Merx, Marc W.
A1  - Koeppel, Thomas A.
A1  - Liehn, Elisa A.
A1  - Zernecke, Alma
T1  - Establishment of a New Murine Elastase-Induced Aneurysm Model Combined with Transplantation
T2  - PLOS ONE
N2  - Introduction: The aim of our study was to develop a reproducible murine model of elastase-induced aneurysm formation combined with aortic transplantation. 
Methods: Adult male mice (n = 6-9 per group) underwent infrarenal, orthotopic transplantation of the aorta treated with elastase or left untreated. Subsequently, both groups of mice were monitored by ultrasound until 7 weeks after grafting. 
Results: Mice receiving an elastase-pretreated aorta developed aneurysms and exhibited a significantly increased diastolic vessel diameter compared to control grafted mice at 7 week after surgery (1.11 +/- 0.10 mm vs. 0.75 +/- 0.03 mm; p <= 0.001). Histopathological examination revealed disruption of medial elastin, an increase in collagen content and smooth muscle cells, and neointima formation in aneurysm grafts. 
Conclusions: We developed a reproducible murine model of elastase-induced aneurysm combined with aortic transplantation. This model may be suitable to investigate aneurysm-specific inflammatory processes and for use in gene-targeted animals.
KW  - abdominal aortic-aneurysm
KW  - mouse models
KW  - prediction
KW  - dilation
KW  - rupture
Y1  - 2014
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/11577
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-115774
SN  - 1932-6203
VL  - 9
IS  - 7
ER  -