TY  - JOUR
A1  - Werner, Rudolf A.
A1  - Marcus, Charles
A1  - Sheikhbahaei, Sara
A1  - Solnes, Lilja B.
A1  - Leal, Jeffrey P.
A1  - Du, Yong
A1  - Rowe, Steven P.
A1  - Higuchi, Takahiro
A1  - Buck, Andreas K.
A1  - Lapa, Constantin
A1  - Javadi, Mehrbod S.
T1  - Visual and Semiquantitative Accuracy in Clinical Baseline 123I-Ioflupane SPECT/CT Imaging
T2  - Clinical Nuclear Medicine
N2  - PURPOSE:
We aimed to (a) elucidate the concordance of visual assessment of an initial I-ioflupane scan by a human interpreter with comparison to results using a fully automatic semiquantitative method and (b) to assess the accuracy compared to follow-up (f/u) diagnosis established by movement disorder specialists.

METHODS:
An initial I-ioflupane scan was performed in 382 patients with clinically uncertain Parkinsonian syndrome. An experienced reader performed a visual evaluation of all scans independently. The findings of the visual read were compared with semiquantitative evaluation. In addition, available f/u clinical diagnosis (serving as a reference standard) was compared with results of the human read and the software.

RESULTS:
When comparing the semiquantitative method with the visual assessment, discordance could be found in 25 (6.5%) of 382 of the cases for the experienced reader (ĸ = 0.868). The human observer indicated region of interest misalignment as the main reason for discordance. With neurology f/u serving as reference, the results of the reader revealed a slightly higher accuracy rate (87.7%, ĸ = 0.75) compared to semiquantification (86.2%, ĸ = 0.719, P < 0.001, respectively). No significant difference in the diagnostic performance of the visual read versus software-based assessment was found.

CONCLUSIONS:
In comparison with a fully automatic semiquantitative method in I-ioflupane interpretation, human assessment obtained an almost perfect agreement rate. However, compared to clinical established diagnosis serving as a reference, visual read seemed to be slightly more accurate as a solely software-based quantitative assessment.
KW  - Single-Photon-Emissions-Computertomographie
KW  - SPECT
KW  - Parkinson’s disease
KW  - Parkinsonism
KW  - DaTscan
KW  - 123I-Ioflupane
KW  - SPECT
KW  - SPECT/CT
Y1  - 2018
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/16818
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-168181
SN  - 1536-0229
VL  - 44
IS  - 1
ER  -