TY  - JOUR
A1  - Lapa, Constantin
A1  - Garcia-Velloso, Maria J.
A1  - Lückerath, Katharina
A1  - Samnick, Samuel
A1  - Schreder, Martin
A1  - Otero, Paula Rodriguez
A1  - Schmid, Jan-Stefan
A1  - Herrmann, Ken
A1  - Knop, Stefan
A1  - Buck, Andreas K.
A1  - Einsele, Hermann
A1  - San-Miguel, Jesus
A1  - Kortüm, Klaus Martin
T1  - \(^{11}\)C-methionine-PET in multiple myeloma: a combined study from two different institutions
T2  - Theranostics
N2  - \(^{11}\)C-methionine (MET) has recently emerged as an accurate marker of tumor burden and disease activity in patients with multiple myeloma (MM). This dual-center study aimed at further corroboration of the superiority of MET as positron emission tomography (PET) tracer for staging and re-staging MM, as compared to \(^{18}\)F-2`-deoxy-2`-fluoro-D-glucose (FDG).
78 patients with a history of solitary plasmacytoma (n=4), smoldering MM (SMM, n=5), and symptomatic MM (n=69) underwent both MET- and FDG-PET/computed tomography (CT) at the University Centers of Würzburg, Germany and Navarra, Spain. Scans were compared on a patient and on a lesion basis. Inter-reader agreement was also evaluated. In 2 patients, tumor biopsies for verification of discordant imaging results were available.
MET-PET detected focal lesions (FL) in 59/78 subjects (75.6%), whereas FDG-PET/CT showed lesions in only 47 patients (60.3%; p<0.01), accordingly disease activity would have been missed in 12 patients. Directed biopsies of discordant results confirmed MET-PET/CT results in both cases.
MET depicted more FL in 44 patients (56.4%; p<0.01), whereas in two patients (2/78), FDG proved superior. In the remainder (41.0%, 32/78), both tracers yielded comparable results. Inter-reader agreement for MET was higher than for FDG (κ = 0.82 vs κ = 0.72).
This study demonstrates higher sensitivity of MET in comparison to standard FDG to detect intra- and extramedullary MM including histologic evidence of FDG-negative, viable disease exclusively detectable by MET-PET/CT. MET holds the potential to replace FDG as functional imaging standard for staging and re-staging of MM.
KW  - medicine
KW  - PET/CT
KW  - \(^{11}\)C-methionine
KW  - multiple myeloma
KW  - FDG
Y1  - 2017
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/17203
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-172038
VL  - 7
IS  - 11
ER  -