TY  - JOUR
A1  - Balonov, Ilja
A1  - Kurlbaum, Max
A1  - Koschker, Ann-Cathrin
A1  - Stier, Christine
A1  - Fassnacht, Martin
A1  - Dischinger, Ulrich
T1  - Changes in plasma metabolomic profile following bariatric surgery, lifestyle intervention or diet restriction — insights from human and rat studies
T2  - International Journal of Molecular Sciences
N2  - Although bariatric surgery is known to change the metabolome, it is unclear if this is specific for the intervention or a consequence of the induced bodyweight loss. As the weight loss after Roux-en-Y Gastric Bypass (RYGB) can hardly be mimicked with an evenly effective diet in humans, translational research efforts might be helpful. A group of 188 plasma metabolites of 46 patients from the randomized controlled Würzburg Adipositas Study (WAS) and from RYGB-treated rats (n = 6) as well as body-weight-matched controls (n = 7) were measured using liquid chromatography tandem mass spectrometry. WAS participants were randomized into intensive lifestyle modification (LS, n = 24) or RYGB (OP, n = 22). In patients in the WAS cohort, only bariatric surgery achieved a sustained weight loss (BMI −34.3% (OP) vs. −1.2% (LS), p ≤ 0.01). An explicit shift in the metabolomic profile was found in 57 metabolites in the human cohort and in 62 metabolites in the rodent model. Significantly higher levels of sphingolipids and lecithins were detected in both surgical groups but not in the conservatively treated human and animal groups. RYGB leads to a characteristic metabolomic profile, which differs distinctly from that following non-surgical intervention. Analysis of the human and rat data revealed that RYGB induces specific changes in the metabolome independent of weight loss.
KW  - metabolomics
KW  - phosphatidylcholines
KW  - sphingolipids
KW  - branched-chain amino acids
KW  - obesity
KW  - Roux-en-Y Gastric Bypass
KW  - rodent model
KW  - insulin resistance
Y1  - 2023
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/30446
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-304462
SN  - 1422-0067
VL  - 24
IS  - 3
ER  -