TY - JOUR
A1 - GrĂ¼ndemann, Dirk
A1 - Gorboulev, Valentin
A1 - Gambaryan, Stepan
A1 - Veyhl, Maike
A1 - Koepsell, Hermann
T1 - Drug excretion mediated by a new prototype of polyspecific transporter
N2 - CATIO~IC drugs of different types and structures (antihistaminics, antiarrhythmics, sedatives, opiates, cytostatics and antibiotics, for example) are excreted in mammals by epithelial cells of the renal proximal tubules and by hepatocytes in the liver1-4. In the proximal tubules, two functionally disparate transport systems are involved which are localized in the basolateral and luminal plasma membrane and are different from the previously identified neuronal monoamine transporters and A TP-dependent multidrug exporting proteins1-3,5-12. Here we report the isolation of a complementary DNA from rat kidney that encodes a 556-amino-acid membrane protein, OCT1, which has the functional characteristics of organic cation uptake over the basolateral membrane of renal proximal tubules and of organic cation uptake into hepatocytes. OCTl is not homologous to any other known protein and is found in kidney, liver and intestine. As OCTl translocates hydrophobic and hydrophilic organic cations of different structures, it is considered to be a new prolotype of polyspecific transporters that are important for drug elimination.
KW - Biologie
Y1 - 1994
UR - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/4955
UR - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-59327
ER -