TY  - JOUR
A1  - Schmitt, Jana
A1  - Backes, Christina
A1  - Nourkami-Tutdibi, Nasenien
A1  - Leidinger, Petra
A1  - Deutscher, Stephanie
A1  - Beier, Markus
A1  - Gessler, Manfred
A1  - Graf, Norbert
A1  - Lenhof, Hans-Peter
A1  - Keller, Andreas
A1  - Meese, Eckart
T1  - Treatment-independent miRNA signature in blood of wilms tumor patients
T2  - BMC Genomics
N2  - Background
Blood-born miRNA signatures have recently been reported for various tumor diseases. Here, we compared the miRNA signature in Wilms tumor patients prior and after preoperative chemotherapy according to SIOP protocol 2001.
Results
We did not find a significant difference between miRNA signature of both groups. However both, Wilms tumor patients prior and after chemotherapy showed a miRNA signature different from healthy controls. The signature of Wilms tumor patients prior to chemotherapy showed an accuracy of 97.5% and of patients after chemotherapy an accuracy of 97.0%, each as compared to healthy controls.
Conclusion
Our results provide evidence for a blood-born Wilms tumor miRNA signature largely independent of four weeks preoperative chemotherapy treatment.
KW  - miRNA
Y1  - 2012
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/12403
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-124034
VL  - 13
IS  - 379
ER  -