TY  - JOUR
A1  - Schartl, Manfred
A1  - Kneitz, Susanne
A1  - Wilde, Brigitta
A1  - Wagner, Toni
A1  - Henkel, Christiaan V.
A1  - Spaink, Hermann P.
A1  - Meierjohann, Svenja
T1  - Conserved expression signatures between medaka and human pigment cell tumors
N2  - Aberrations in gene expression are a hallmark of cancer cells. Differential tumor-specific transcript levels of single genes or whole sets of genes may be critical for the neoplastic phenotype and important for therapeutic considerations or useful as biomarkers. As an approach to filter out such relevant expression differences from the plethora of changes noted in global expression profiling studies, we searched for changes of gene expression levels that are conserved. Transcriptomes from massive parallel sequencing of different types of melanoma from medaka were generated and compared to microarray datasets from zebrafish and human melanoma. This revealed molecular conservation at various levels between fish models and human tumors providing a useful strategy for identifying expression signatures strongly associated with disease phenotypes and uncovering new melanoma molecules.
KW  - Biologie
Y1  - 2012
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/6550
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-75848
ER  -