TY  - JOUR
A1  - Canessa, Andrea
A1  - Pozzi, Nicolò G.
A1  - Arnulfo, Gabriele
A1  - Brumberg, Joachim
A1  - Reich, Martin M.
A1  - Pezzoli, Gianni
A1  - Ghilardi, Maria F.
A1  - Matthies, Cordula
A1  - Steigerwald, Frank
A1  - Volkmann, Jens
A1  - Isaias, Ioannis U.
T1  - Striatal Dopaminergic Innervation Regulates Subthalamic Beta-Oscillations and Cortical-Subcortical Coupling during Movements: Preliminary Evidence in Subjects with Parkinson's Disease
T2  - Frontiers in Human Neuroscience
N2  - Activation of the basal ganglia has been shown during the preparation and execution of movement. However, the functional interaction of cortical and subcortical brain areas during movement and the relative contribution of dopaminergic striatal innervation remains unclear. We recorded local field potential (LFP) activity from the subthalamic nucleus (STN) and high-density electroencephalography (EEG) signals in four patients with Parkinson’s disease (PD) off dopaminergic medication during a multi-joint motor task performed with their dominant and non-dominant hand. Recordings were performed by means of a fully-implantable deep brain stimulation (DBS) device at 4 months after surgery. Three patients also performed a single-photon computed tomography (SPECT) with [123I]N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)nortropane (FP-CIT) to assess striatal dopaminergic innervation. Unilateral movement execution led to event-related desynchronization (ERD) followed by a rebound after movement termination event-related synchronization (ERS) of oscillatory beta activity in the STN and primary sensorimotor cortex of both hemispheres. Dopamine deficiency directly influenced movement-related beta-modulation, with greater beta-suppression in the most dopamine-depleted hemisphere for both ipsi- and contralateral hand movements. Cortical-subcortical, but not interhemispheric subcortical coherencies were modulated by movement and influenced by striatal dopaminergic innervation, being stronger in the most dopamine-depleted hemisphere. The data are consistent with a role of dopamine in shielding subcortical structures from an excessive cortical entrapment and cross-hemispheric coupling, thus allowing fine-tuning of movement.
KW  - beta oscillations
KW  - Parkinson’s disease
KW  - motor control
KW  - movement disorders
KW  - imaging
KW  - subthalamic nucleus
KW  - coherence analysis
Y1  - 2016
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/16406
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-164061
VL  - 10
IS  - 611
ER  -