TY  - JOUR
A1  - Rottlaender, Andrea
A1  - Kuerten, Stefanie
T1  - Stepchild or prodigy? Neuroprotection in multiple sclerosis (MS) research
T2  - International Journal of Molecular Sciences
N2  - Multiple sclerosis (MS) is an autoimmune disorder of the central nervous system (CNS) and characterized by the infiltration of immune cells, demyelination and axonal loss. Loss of axons and nerve fiber pathology are widely accepted as correlates of neurological disability. Hence, it is surprising that the development of neuroprotective therapies has been neglected for a long time. A reason for this could be the diversity of the underlying mechanisms, complex changes in nerve fiber pathology and the absence of biomarkers and tools to quantify neuroregenerative processes. Present therapeutic strategies are aimed at modulating or suppressing the immune response, but do not primarily attenuate axonal pathology. Yet, target-oriented neuroprotective strategies are essential for the treatment of MS, especially as severe damage of nerve fibers mostly occurs in the course of disease progression and cannot be impeded by immune modulatory drugs. This review shall depict the need for neuroprotective strategies and elucidate difficulties and opportunities.
KW  - experimental autoimmune encephalomyelitis
KW  - white matter
KW  - lesions
KW  - remyelination
KW  - multiple sclerosis
KW  - regeneration
KW  - neuroprotection
KW  - degeneration
KW  - axonal damage
KW  - neurodegeneration
KW  - pathology
KW  - sodium channels
KW  - axonal injury
KW  - central nervous system
Y1  - 2015
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/14841
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-148416
VL  - 16
ER  -