TY  - JOUR
A1  - Vonhof, S.
A1  - Sirén, Anna-Leena
T1  - Reversal of µ-opioid-mediated respiratory depression by α2-adrenoceptor antagonism
N2  - The present study was performed in order to evaluate the effects of the selective 02- adrenoceptor antagonist 6-chloro-2,3,4,5-tetrahydro-3-methyl-1H-3-benzazepine (SK&F 86466) on dermorphin-induced analgesia, respiratory depression and inhibition of locomotor activity in the conscious rat. Intracerebroventricular (icv) administration of dermorphin (3 nmol/rat) decreased respiration rate and relative ventilatory minute volume maximally by 38 % and 50 % of baseline respectively. SK&F 86466 dose-dependently reversed the dermorphin-induced depression of ventilatory parameters, while SK&F 86466 exerted no effect on dermorphin-induced analgesia or depression of locomotor activity due to catalepsia. It appears, therefore, that a 2-adrenoceptors selectively interact with Jl2-opioid-receptor mediated effects, such as respiratory depression, but are not involved in the modulation of Jl,-opioid-related effects, such as supraspinal analgesia and depression of locomotor activity.
KW  - Biowissenschaften
Y1  - 1991
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/4565
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-47454
ER  -