TY  - JOUR
A1  - Karppanen, H.
A1  - Sirén, Anna-Leena
A1  - Eskeli-Kaivosoja, Alice
T1  - Central cardiovascular and thermal effects of Prostaglandin F2α in rats
N2  - Administration of PGF 2IX (0.2-6.4 J.lg) into the lateral cerebral ventricle (i.c.v.) induced dosedependent increases in blood pressure , heart rate and body temperature in urethane-anaesthetised rats, but had no effect on these parameters when the same dose range was administered intravenously. Peripheral pretreatment with sodium meclofenamate (50 mg/kg s.c.) sltifted all the dose-response curves for PGF 2IX (i.c.v.) to the left, but indomethacin (50 mg/kg s.c.) did not significantly affect those changes. Central pretreatment with sodiurn meclofenamate or indomethacin (1.25 mg per rat i.c.v.) failed to modify significantly the effects of centrally administered PGF 2IX' The results support previous suggestions that PGF 2IX may participate in the central control of the cardiovascular and thermoregulatory systems, and also suggest that there may be differences in the sites and/or modes of action between sodiurn meclofenamate and indomethacin.
KW  - Prostaglandine
Y1  - 1979
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/4591
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-47955
ER  -