TY  - JOUR
A1  - Sirén, Anna-Leena
A1  - Feuerstein, G.
T1  - Effect of T-2 toxin on regional blood flow and vascular resistance in the conscious rat
N2  - The acute effect ofT-2 toxemia on local blood flow and vascular resistance in hindquarter. mesenteric. and renal vascular beds was continuously measured by the directional pulsed Doppler technique in conscious, male Sprague-Dawley rats. Intravenous injection ofT-2 toxin (I mg/kg) in the conscious rat reduced blood flow and increased vascular resistance in all blood vessels studied but had no significant effect on mean arterial pressure or heart rate. The blood flow in hindquarters gradually decreased to a minimum of -77 ± 9% (mean ±SE) 6 hr after the toxin injection. The hindquarter vascular resistance concomitantly increased to a maximum value of + 323 ± 69% above thc resistance before toxin administration. Mesenteric and renal blood flow initially increased (slightly) and then gradually decreased. The maximum drop of blood flow, -90 ± 13% and -76 ± 13% for the mesenteric and renal vascular beds, respectively, was achieved 4 hr after T-2 toxin injection and the blood flow values remained low for up to 6 hr. Simultaneously with the impairment of
KW  - Neurobiologie
Y1  - 1986
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/6109
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-63293
ER  -