TY  - JOUR
A1  - Sirén, Anna-Leena
A1  - Svarström-Fraser, M.
A1  - Paakkari, I.
T1  - Central cardiovascular effects of the endoperoxide analogue U-46619 i.c.v. in rats
N2  - Thromboxanes are abundantly present in the rat brain but their possible physiological functions in the brain are not known. The prostaglandin endoperoxide analogue U-46619 is a selective agonist of TxA2 receptors in many peripheral tissues. In the present study the ·central cardiovascular and ventilatory effects of U-46619 were investigated in rats. In conscious spontaneously hypertensive rats (SHR) U-46619 (1-100 nmol/kg i.c.v.) induced a strong dose-related increase in blood pressure but had no significant effect on heart rate. In conscious normotensive rats (NR) neither blood pressure nor heart rate was significantly affected. Furthermore, U-46619 (0.1-100 nmol/kg i.c.v.) had no significant effect on blood pressure, heart rate or ventilation in urethane-anaesthetised NR . The results demonstrate an increased sensitivity of SHR to TxA2.
KW  - Medizin
Y1  - 1985
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/4586
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-49064
ER  -