TY  - JOUR
A1  - Paakkari, P.
A1  - Paakkari, I.
A1  - Landes, P.
A1  - Sirén, Anna-Leena
A1  - Feuerstein, G.
T1  - Respiratory \(\mu\)-Opioid and benzodiazepine interactions in the understrained rat
N2  - lnteractions of p-opioid receptors with the benzodiazepine system were studied by examining the modulatory effects of flumazenil (a benzodiazepine antagonist) and alprazolam (a benzodiazepine agonist) on the respiratory effects ofthe opioid peptide dermorphin. Dermorphin, 1-30 nmol administered i.c.v., to conscious, unrestrained rats decreased ventilation rate (VR) and minute volume (MV) dose-dependently. The ventilatory depression was antagonized by naloxone and by the benzodiazepine antagonist flumazenil. The benzodiazepine alprazolam potentiateri the respiratory inhibition of a small (I nmol) dose of dermorphin but antagonized that of a higher dos:~ (3 nmol). The results suggest that the benzodiazepine/GABA receptor complex modulates respiratory depression induced by centrat p-receptor Stimulation in the rat.
KW  - Neurobiologie
KW  - dermorphin
KW  - opioid receptors
KW  - opioid-benzodiazepine interactions
KW  - respiration
KW  - flumazenil
KW  - benzodiazepine antagonist.
Y1  - 1993
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/6054
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-62974
ER  -