TY  - JOUR
A1  - Tylek, Tina
A1  - Blum, Carina
A1  - Hrynevich, Andrei
A1  - Schlegelmilch, Katrin
A1  - Schilling, Tatjana
A1  - Dalton, Paul D
A1  - Groll, Jürgen
T1  - Precisely defined fiber scaffolds with 40 μm porosity induce elongation driven M2-like polarization of human macrophages
T2  - Biofabrication
N2  - Macrophages are key players of the innate immune system that can roughly be divided into the pro-inflammatory M1 type and the anti-inflammatory, pro-healing M2 type. While a transient initial pro-inflammatory state is helpful, a prolonged inflammation deteriorates a proper healing and subsequent regeneration. One promising strategy to drive macrophage polarization by biomaterials is precise control over biomaterial geometry. For regenerative approaches, it is of particular interest to identify geometrical parameters that direct human macrophage polarization. For this purpose, we advanced melt electrowriting (MEW) towards the fabrication of fibrous scaffolds with box-shaped pores and precise inter-fiber spacing from 100 μm down to only 40 μm. These scaffolds facilitate primary human macrophage elongation accompanied by differentiation towards the M2 type, which was most pronounced for the smallest pore size of 40 μm. These new findings can be important in helping to design new biomaterials with an enhanced positive impact on tissue regeneration.
KW  - cell elongation
KW  - human macrophages
KW  - melt electrowriting (MEW)
KW  - macrophage polarization
KW  - 3D scaffolds
Y1  - 2020
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/25401
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-254012
VL  - 12
IS  - 2
ER  -