TY  - JOUR
A1  - Schneider-Schaulies, Jürgen
A1  - Schneider-Schaulies, Sibylle
A1  - Brinkmann, R.
A1  - Tas, P.
A1  - Halbrügge, M.
A1  - Walter, U.
A1  - Holmes, H.C.
A1  - ter Meulen, Volker
T1  - HIV-1 gp120 receptor on CD4-negative brain cells activates a tyrosine kinase
N2  - Human immunodeficiency virus (HIV-1) infection in the human brain Ieads to characteristic neuropathological changes, which may result indirectly from interactions of the envelope glycoprotein gp 120 with neurons and/or glial cells. We therefore investigated the binding of recombinant gp120 (rgp120) to human neural cells and its effect on int~acellular.s.ignallin~. Herewe pre~ent evidence that rgp120, besides binding to galactocerebroside or galactosyl-sulfatlde, spec1f1cally bmds to a protem receptor of a relative molecular mass of approximately 180,000 Da (180 kDa) pre~ent. on the CD4-negative glioma cells D-54, but not on Molt4 T lymphocytes. Binding of rgp120 to this receptor rap1dly 1nduced a tyrosine-specific protein kinase activity leading to tyrosine phosphorylation of 130- and 115-kDa p~oteins. The c~ncentration of intracellular calciumwas not affected by rgp120 in these cells. Our data suggest a novel Signal transduc1ng HIV-1 gp120 receptor on CD4-negative glial cells, which may contribute to the neuropathological changes observed in HIV-1-infected brains.
KW  - Immunologie
Y1  - 1992
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/5853
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-54872
ER  -