TY  - JOUR
A1  - Lange, Florian
A1  - Steigerwald, Frank
A1  - Malzacher, Tobias
A1  - Brandt, Gregor Alexander
A1  - Odorfer, Thorsten Michael
A1  - Roothans, Jonas
A1  - Reich, Martin M.
A1  - Fricke, Patrick
A1  - Volkmann, Jens
A1  - Matthies, Cordula
A1  - Capetian, Philipp D.
T1  - Reduced Programming Time and Strong Symptom Control Even in Chronic Course Through Imaging-Based DBS Programming
T2  - Frontiers in Neurology
N2  - Objectives: Deep brain stimulation (DBS) programming is based on clinical response testing. Our clinical pilot trial assessed the feasibility of image-guided programing using software depicting the lead location in a patient-specific anatomical model.
Methods: Parkinson's disease patients with subthalamic nucleus-DBS were randomly assigned to standard clinical-based programming (CBP) or anatomical-based (imaging-guided) programming (ABP) in an 8-week crossover trial. Programming characteristics and clinical outcomes were evaluated.
Results: In 10 patients, both programs led to similar motor symptom control (MDS-UPDRS III) after 4 weeks (medicationOFF/stimulationON; CPB: 18.27 ± 9.23; ABP: 18.37 ± 6.66). Stimulation settings were not significantly different, apart from higher frequency in the baseline program than CBP (p = 0.01) or ABP (p = 0.003). Time spent in a program was not significantly different (CBP: 86.1 ± 29.82%, ABP: 88.6 ± 29.0%). Programing time was significantly shorter (p = 0.039) with ABP (19.78 ± 5.86 min) than CBP (45.22 ± 18.32).
Conclusion: Image-guided DBS programming in PD patients drastically reduces programming time without compromising symptom control and patient satisfaction in this small feasibility trial.
KW  - directional deep brain stimulation
KW  - image-guided programming
KW  - subthalamic nucleus
KW  - chronic stimulation
KW  - randomized controlled double-blind study
KW  - Parkinson's disease
Y1  - 2021
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/24963
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-249634
SN  - 1664-2295
VL  - 12
ER  -