TY  - JOUR
A1  - Isaias, Ioannis U.
A1  - Volkmann, Jens
A1  - Marzegan, Alberto
A1  - Marotta, Giorgio
A1  - Cavallari, Paolo
A1  - Pezzoli, Gianni
T1  - The Influence of Dopaminergic Striatal Innervation on Upper Limb Locomotor Synergies
T2  - PLoS One
N2  - To determine the role of striatal dopaminergic innervation on upper limb synergies during walking, we measured arm kinematics in 13 subjects with Parkinson disease. Patients were recruited according to several inclusion criteria to represent the best possible in vivo model of dopaminergic denervation. Of relevance, we included only subjects with normal spatio-temporal parameters of the stride and gait speed to avoid an impairment of upper limbs locomotor synergies as a consequence of gait impairment per se. Dopaminergic innervation of the striatum was measured by FP-CIT and SPECT. All patients showed a reduction of gait-associated arms movement. No linear correlation was found between arm ROM reduction and contralateral dopaminergic putaminal innervation loss. Still, a partition analysis revealed a 80% chance of reduced arm ROM when putaminal dopamine content loss was >47%. A significant correlation was described between the asymmetry indices of the swinging of the two arms and dopaminergic striatal innervation. When arm ROM was reduced, we found a positive correlation between upper-lower limb phase shift modulation ( at different gait velocities) and striatal dopaminergic innervation. These findings are preliminary evidence that dopaminergic striatal tone plays a modulatory role in upper-limb locomotor synergies and upper-lower limb coupling while walking at different velocities.
KW  - pet
KW  - Parkinsons disease
KW  - basal ganglia
KW  - spinal-cord
KW  - walking
KW  - gait
KW  - arm
KW  - coordination
KW  - movements
Y1  - 2012
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/13397
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-133976
VL  - 7
IS  - 12
ER  -