TY  - JOUR
A1  - Schroeter, Matthias L.
A1  - Pawelke, Sarah
A1  - Bisenius, Sandrine
A1  - Kynast, Jana
A1  - Schuemberg, Katharina
A1  - Polyakova, Maryna
A1  - Anderl-Straub, Sarah
A1  - Danek, Adrian
A1  - Fassbender, Klaus
A1  - Jahn, Holger
A1  - Jessen, Frank
A1  - Kornhuber, Johannes
A1  - Lauer, Martin
A1  - Prudlo, Johannes
A1  - Schneider, Anja
A1  - Uttner, Ingo
A1  - Thöne-Otto, Angelika
A1  - Otto, Markus
A1  - Diehl-Schmid, Janine
T1  - A Modified Reading the Mind in the Eyes Test Predicts Behavioral Variant Frontotemporal Dementia Better Than Executive Function Tests
T2  - Frontiers in Aging Neuroscience
N2  - Behavioral variant frontotemporal dementia (bvFTD) is characterized by deep alterations in behavior and personality. Although revised diagnostic criteria agree for executive dysfunction as most characteristic, impairments in social cognition are also suggested. The study aimed at identifying those neuropsychological and behavioral parameters best discriminating between bvFTD and healthy controls. Eighty six patients were diagnosed with possible or probable bvFTD according to Rascovsky et al. (2011) and compared with 43 healthy age-matched controls. Neuropsychological performance was assessed with a modified Reading the Mind in the Eyes Test (RMET), Stroop task, Trail Making Test (TMT), Hamasch-Five-Point Test (H5PT), and semantic and phonemic verbal fluency tasks. Behavior was assessed with the Apathy Evaluation Scale, Frontal Systems Behavioral Scale, and Bayer Activities of Daily Living Scale. Each test’s discriminatory power was investigated by Receiver Operating Characteristic curves calculating the area under the curve (AUC). bvFTD patients performed significantly worse than healthy controls in all neuropsychological tests. Discriminatory power (AUC) was highest in behavioral questionnaires, high in verbal fluency tasks and the RMET, and lower in executive function tests such as the Stroop task, TMT and H5PT. As fluency tasks depend on several cognitive functions, not only executive functions, results suggest that the RMET discriminated better between bvFTD and control subjects than other executive tests. Social cognition should be incorporated into diagnostic criteria for bvFTD in the future, such as in the International Classification of Diseases (ICD)-11, as already suggested in the Diagnostic and Statistical Manual for Mental Disorders (DSM)-5.
KW  - behavioral variant frontotemporal dementia
KW  - diagnostic criteria
KW  - executive function
KW  - social cognition
KW  - theory of mind
Y1  - 2018
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/23425
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-234254
VL  - 10
ER  -