TY  - JOUR
A1  - Fan, Sook-Ha
A1  - Ebner, Patrick
A1  - Reichert, Sebstian
A1  - Hertlein, Tobias
A1  - Zabel, Susanne
A1  - Lankapalli, Aditya Kumar
A1  - Nieselt, Kay
A1  - Ohlsen, Knut
A1  - Götz, Friedrich
T1  - MpsAB is important for Staphylococcus aureus virulence and growth at atmospheric CO2 levels
T2  - Nature Communications
N2  - The mechanisms behind carbon dioxide (CO2) dependency in non-autotrophic bacterial isolates are unclear. Here we show that the Staphylococcus aureus mpsAB operon, known to play a role in membrane potential generation, is crucial for growth at atmospheric CO2 levels. The genes mpsAB can complement an Escherichia coli carbonic anhydrase (CA) mutant, and CA from E. coli can complement the S. aureus delta-mpsABC mutant. In comparison with the wild type, S. aureus mps mutants produce less hemolytic toxin and are less virulent in animal models of infection. Homologs of mpsA and mpsB are widespread among bacteria and are often found adjacent to each other on the genome. We propose that MpsAB represents a dissolved inorganic carbon transporter, or bicarbonate concentrating system, possibly acting as a sodium bicarbonate cotransporter.
KW  - bacterial physiology
KW  - bacteriology
KW  - pathogens
Y1  - 2019
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/22762
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-227624
VL  - 10
ER  -